CRB was the prime consultant for the design of this new biological production facility. The 56,000 sq. ft. facility manufactures aerobe and anaerobe bacterins and viral antigens. The facility was designed to meet European Union GMP regulatory requirements.
The facility contains state-of-the-art fermentation and bioreactor suites with vessels of various sizes, seed scale-up areas, inactivation and downstream processing areas, blending areas, freeze drying and filling suites. In this project isolation technology was evaluated during conceptual design for use in the aseptic filling suite. Support facilities include media prep, tank and equipment cleaning, clean and dirty staging and storage.
Process utilities include Clean-In-Place, Water for Injection, pure steam, clean compressed air and a waste kill system. Project included the design of a new chilled water system operates at 42°F with a 12°F temperature differential to adequately support space dehumidification loads. The pumping system is a primary/secondary system with constant primary speed pumps and variable speed secondary pumps.
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