CRB provided process and instrumentation design services for this 78,000 sq. ft. laboratory facility. The facility's purpose is to provide Kilo Laboratory scale research and development, pre-clinical batches for Bulk Pharmaceutical Chemicals and Active Pharmaceutical Ingredients for both oral dosage and parenteral materials.
The scope of services included conceptual design, detailed design and construction period services for the process and process equipment. The facility consists of four Kilo Laboratories and one Hydrogenation room each equipped with deflagration capabilities and three drying rooms containing forced air dryers, vacuum dryers, and lyophilyzers for removal of solvents and water from solid filter cakes and a milling room for solid product processing.
The project had chemical reactor systems ranging from 50 liters to 160 liters. The reactor systems were set up within fume control enclosures, and were specially configured for highly reactive chemical formulations. Most reactors were glass lined carbon steel vessels with glass overheads. One reactor system was Hastelloy for low temperature processing.
Additional process equipment included Rotovap and wiped film evaporators, solid product separation filters, clarification filters, milling equipment, reactor feed vessels, condensers and condensate receivers. Support systems included process vent scrubbers, ventilation exhaust scrubbers, bulk solvent distribution, and process vacuum systems. Process support utilities included a glycol based process chiller, an engineered fluid-based process heat exchange unit for processing at -60 degrees C and process vacuum systems.
|
