You expect innovation from the world of engineering. You also expect customized solutions that fit your needs. CRB offers customized solutions that optimize the use of existing components while maximizing the benefits of new technology and systems available in today's marketplace.

As projects develop and unfold, objectives will evolve and change. CRB understands this and our project teams are positioned to respond. This requires maximum flexibility on our part. Our multi-discipline teams include leading industry experts, are very familiar with the changing nature of process design and facility projects. Because CRB's approach is as flexible as your changing needs, you gain a new level of competitive advantage. Your project unfolds with today's issues and tomorrow's forecasts addressed. This allows your company to determine how current and future issues can most effectively be addressed in your project today.

CRB's Areas of Expertise include:

Mechanical Systems	Piping	Process Simulation
Process Systems	Instrumentation/Automation	Start-up & Commissioning
Utilities	Architecture	Additional Services
Electrical	Process Facilities Integration

Mechanical Systems

Mechanical equipment and systems design and specification
Piping and specialty item design and specification
Heating, ventilating and air conditioning systems
Tight tolerance temperature and humidity control systems
Clean Rooms
Contamination sensitive production and research areas
Design and constructability reviews
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Process Systems

Project definition and scope development
Process development and scale-up
Pilot plant design
Reactor design and kinetic analysis
Fermentation processes and fermentor design
Cell culture systems, roller bottle or bioreactor based
Isolation and purification processes
Specialty chemicals
Batch and continuous processes
Filling and packaging systems
Product recovery and purification systems
HazOp and safety reviews
Process equipment and systems
Specification and technical bid evaluation
SOP development
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Process Simulation (download a PDF brochure)

Conceptual design
Process optimization
De-bottlenecking
Utility sizing
Cost of good analysis
Production scheduling

Utilities

Central utility plants
CIP, SIP, pure steam, sterile gases, etc.
WFI, USP, and other high purity water systems
Process waste containment and kill systems
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Electrical

Medium voltage to 15,000 volts
Low voltage 120/208 and 277/480
Surge protection
Motor controls
Lighting
Grounding
Lightning protection
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Piping

3D layouts
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Instrumentation/Automation (download a PDF brochure)

P&ID Development
Process variable measurement and control
PLC's, SCADA and Distributed Control Systems
Single loop and relay logic
Equipment automation
Control valve sizing and selection
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Architecture (download a PDF brochure)

Building/Site due-diligence studies and design

Site Feasibility and Selection

Master Planning

Space Planning

Process Architecture

Materials Evaluation/Selection
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Process Facilities Integration

Integration of equipment and processes into facilities
Manufacturing and process facility programming
Facility cGMP planning
Facility cGMP review and compliance
Planning and design of cGMP facility specialties
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Start-up, Commissioning and Qualification
(download the Commissioning brochure PDF)

System commissioning and balancing (NEBB Certified)
HEPA filter Integrity Testing
Clean Room testing and certification (NEBB Certified)
Biological Safety Cabinet Testing
Weld program qualification and inspection
Calibration
Control Loop Tuning
Vendor/Factory Acceptance Testing
Training
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Additional Services

Program Management
GMP Design Compliance Review
Value Engineering
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