Biogen Named ENR Southeast Best Project

Biogen Named ENR Southeast Best Project
Posted: Aug 24 2017
CRB is pleased to announce that the Biogen’s LSM 3X Capacity Upgrades Project in Research Triangle Park (RTP), NC, has won an Award of Merit in the Manufacturing Category for ENR Southeast’s 2017 ‘Best Projects’  competition.

Biogen’s LSM 3X Capacity Upgrades

This biopharmaceutical design-build manufacturing project included the deconstruction of seven specific manufacturing areas totaling over 100,000-sq.-ft. The scope included re-building the seed train bioreactor suite with the inclusion of N-1 perfusion equipment, reducing equipment downtime through the debottlenecking of CIP distribution and the addition of a new CIP skid, implementation of new process analytics to reduce process sampling requirements, and additional harvest capacity to handle the increase in cell mass.

The re-construction effort resulted in procurement and the installation of nine new vessels, 14 process skids, more than 1,000 sanitary diaphragm valves, and 1,500 process instruments. This effort was completed within a three month shutdown schedule that also include time for commissioning services. All manufacturing areas were returned to Biogen at or ahead of schedule.

For this upgrade project, the title truly says it all! The “3X Capacity Upgrade Project” title is entirely accurate of the initial design goal. In the literal sense, the goal was to increase Biogen’s yield by three times from the original design of the facility. Proudly, implementation of this design was accomplished without an increase in physical space and will allow Biogen to continue to deliver lifesaving treatments at lower costs. The results of these upgrades are aesthetically stunning and the alterations are unrecognizable from the existing facility! The design-build team successfully created a functional facility which adheres to strict regulation guidelines. The project was a highly collaborative design effort with Biogen, DPR Construction (General Contractor/Construction Manager), CRB (Lead Design Firm), Fluhrer Reed PA (Structural Engineer) and industry trade partners to achieve project goals and position Biogen for future products.

ENR ‘Best Projects’ Competition
This award recognizes construction and design excellence in the Southeast region for 2017 projects built in Alabama, Florida, Georgia, North Carolina, South Carolina and Tennessee. This year, ENR judges collectively reviewed nearly 90 entries before honoring the projects.

The 2017 winners will be profiled in depth in the November 6/13 print edition of ENR Southeast. ENR Southeast will honor each winning project at their November 17th awards luncheon, to be held this year at the Omni Orlando Resort at Champions Gate. Additionally, this project will later become an ENR contestant at the National level.