Engineering

How to incorporate highly potent drug products into your facility

Jeff Fedor
There are many benefits to adding highly potent drug products to your portfolio, including increasing demand and generating potentially higher profit margins. Making the decision to incorporate highly potent drug products into your manufacturing facility can be a challenging process.
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Sustainability matters: Working together toward a sustainable world

Sustainability matters: Working together toward a sustainable world

Sharbel El Haber
Governments, businesses and individuals are all seeking to create a more sustainable world to cut costs and promote environments that are healthier and more viable in the long term. From simple changes like banning plastic bags and promoting recycling programs to more complex ones like using hybrid and electric vehicles and tapping into building and design efficiencies, "sustainability” has become a household word. The word “green” is often used to describe a world becoming very conscious of ways to save the environment while championing cost efficiencies. 
Effective and Efficient Waste-stream Management in a Food Facility

Effective and Efficient Waste-stream Management in a Food Facility

Every manufacturer must address it—the ever-present elephant in the room: WASTE. Companies small and large, across all industries, are faced with waste in their manufacturing process. From raw ingredients to packaging, every stage of the manufacturing process must take waste into consideration and how to manage it. 
Ten Reasons Why You Should Build a Process Model

Ten Reasons Why You Should Build a Process Model

A process model can be anything from a simple excel spreadsheet to a complex model that includes all aspects of a real-world manufacturing plant. However, the best model does not include everything. It only includes what is necessary to answer questions.
An Engineer Inside the Classroom: How the Built Environment Influences Engineering Education

An Engineer Inside the Classroom: How the Built Environment Influences Engineering Education

Gerry Williams
As an adjunct engineering professor at a large university, I have had the opportunity to see the impact that the built environment has on my engineering students. Innovative features in a classroom can greatly enhance learning capabilities, whereas poor design (and even poor ventilation) can hinder cognition and learning.
Improving Operational Efficiency of a Pet Nutrition Facility

Improving Operational Efficiency of a Pet Nutrition Facility

Niranjan Kulkarni
A pet food company hired CRB to perform an industrial engineering study for its pet food nutrition facility. Current work practices were not efficient and were highly manual and repetitious.
Transformers: Ensuring Efficient Electrical System Design

Transformers: Ensuring Efficient Electrical System Design

Brad Watford
As clients’ budgets are getting tighter, every penny spent is scrutinized. Both capital and long-term operational costs are evaluated for optimal cost savings. Over the past decade, 3-phase, low-voltage, dry-type transformer efficiency has become a hot topic for owners and specifying engineers seeking to save money on the long-term operational costs within a facility. 
Leveraging your Packaging Consulting Engineer

Leveraging your Packaging Consulting Engineer

Renee Benson and Forrest Carter
It’s true – you only get one opportunity to make a good first impression. For a manufacturing company, a customer’s first impression often comes in the form of product packaging. It would seem fitting then that experts would be engaged in developing packaging to ensure best practices are being utilized in an efficient and aesthetically pleasing way.
FSMA: Engineering for Food Safety

FSMA: Engineering for Food Safety

Pablo Coronel and Niranjan Kulkarni
Food safety is non-negotiable. Any contamination in products that may reach customers is a liability and must be recalled. Recalls are now mandated by the Food Safety Modernization Act (FSMA) that values risk-based prevention for maintaining food safety throughout the whole supply chain.
Continuous OSD Manufacturing

Continuous OSD Manufacturing

David DiProspero
Why the Shift from Batch to Continuous for Pharmaceutical Oral Solid Dosage Form Tablet Manufacture is Now Upon Us
Taste is King

Taste is King

Pablo Coronel
Understanding quirks, objectives and language are challenging for food industry engineers and consumers alike. While eating is necessary for nutritious living, it also has to be a pleasurable experience.  Food products are aimed to please the consumer in several ways. Engineers are consistently taught about ideal processes based on purity and degree of polymerization, but flavor, despite its importance, gets overlooked.  
Facility of the Present

Facility of the Present

Andrew Harris
There has been so much industry discussion and debate over the facility of the future construct (or FutureFacility™) and how it can be reimagined that sometimes we lose focus of the common pitfalls of young biotech and pharmaceutical commercial manufacturing facilities.
Improving Operations Can Save Real Dough

Improving Operations Can Save Real Dough

Niranjan Kulkarni
Like any resource-constrained industry facing uncertain demands and external competition, the food industry is under constant pressure to reduce operating expenses, shorten lead times, improve flexibility and increase throughput. Designing new facilities or expanding existing ones is an expensive undertaking and is often ranked low on a list of options for companies.
Optimizing Facility, Process & Packaging Design for Food Safety

Optimizing Facility, Process & Packaging Design for Food Safety

Implementing Prevention Practices Now for FSMA Compliance Tomorrow As many as 48 million Americans – or 1 in 6 - get sick, 128,000 are hospitalized, and 3,000 die each year of foodborne diseases, according to the Centers for Disease Control and Prevention. Food born pathogens, like Salmonella, Ecoli and Listeria, contaminate food somewhere between the farm and our table and are typically the result of poor food safety practices. Contamination can occur in many different types of food, during growth, harvesting, manufacturing, processing, packing, holding and transportation.
So You Have a Biofilm, Now What?

So You Have a Biofilm, Now What?

CRB’s Christa Myers, Associate, Process Specialist and Project Manager, recently held an INTERPHEX Live video chat about the challenges with Biofilms.
Creating a Future Lab within an Aging Infrastructure

Creating a Future Lab within an Aging Infrastructure

Mary Carroll and Scott McNallan and Mike Morris
How do you engage a client in a way that frees his/her mind to the prospects of an open flexible lab design? How do you lead them to see the potential within an old, tired building? Many of our clients, life sciences and otherwise, have antiquated labs in antiquated buildings on campuses that have been built to their limits. 
Drug Supply Chain Security Act – Enterprise Disruption

Drug Supply Chain Security Act – Enterprise Disruption

Steve Peterson and Mike McKillop
The Drug Supply Chain Security Act (DSCSA) 2017 deadline to domestically ship your Rx products with a unique serial identification number is now less than three (3) years away.  Taking into account contingency, this leaves companies approximately 2½ years to implement an enterprise wide serialization system that will impact nearly every group within their organization.  The disruption to existing manufacturing and distribution processes will be significant. 
Next Generation Biomanufacturing - Leveraging the Benefits of Continuous Closed Processing

Next Generation Biomanufacturing - Leveraging the Benefits of Continuous Closed Processing

Matthew Kennedy and Steve Attig
Steve Attig and Matt Kennedy recently spoke at Interphex 2015 on next generation biopharmaceutical manufacturing facilities that significantly reduce a facility footprint, capital investment, manufacturing cost of goods, and improves utilization of assets when compared to conventional batch processing.
Simulation Software Enhances Packaging Line Design

Simulation Software Enhances Packaging Line Design

Modeling tool helps companies right size equipment for efficiency and savings.
Designing Flexibility into Small Space Renovations

Designing Flexibility into Small Space Renovations

Brian Peasley
Incorporating flexibility into any space can be challenging. With a variety of concepts, tools and equipment at a designer’s disposal, it is easy to get excited about implementing new technology. Still, every renovation project comes with its own unique set of challenges, and there is never a one-size-fits-all solution to incorporate flexibility into a project. In this blog post, I will answer some common questions about how to execute a successful renovation project with flexibility in mind.
Importance of Information Sharing in Cold Chains

Importance of Information Sharing in Cold Chains

Niranjan Kulkarni
To ensure quality of pharmaceutical raw materials and products, it is very important to monitor specific factors throughout supply chain. In cold chains, temperature is closely controlled and monitored.
Leveraging Design To Minimize Risk

Leveraging Design To Minimize Risk

Matthew Kennedy and Matthew Khair
Learn how the application of best practice design principles can help mitigate the risks confronting biotechnology companies when navigating the uncertainty surrounding the demand profile of its product pipeline.
Building a Thoughtful Manufacturing Supply Chain

Building a Thoughtful Manufacturing Supply Chain

J. Lee Emel
In the past 5 years, the biopharmaceutical industry has seen unprecedented change. Precipitated by the need to support a global client base with products that are more targeted, efficacious and cost effective, the challenge to have a robust manufacturing supply chain is more crucial than ever to a company’s survival.
Understanding Waste From A Lean Biopharmaceutical Perspective

Understanding Waste From A Lean Biopharmaceutical Perspective

Niranjan Kulkarni
As pressure to cut costs continues to grow, CRB Operations Improvement specialist, Niranjan Kulkarni, PhD, assists manufacturers in implementing Lean and Six Sigma methodologies to eliminate waste and maximize profits.
Back to the Future: A Retrospective Look Forward At Lab Planning*

Back to the Future: A Retrospective Look Forward At Lab Planning*

Take a look at the picture. Would you believe that this could be the “lab of the future?”
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