Operational Technologies

We've delivered operational excellence in biotech for three decades.

Since we began in 1984, CRB has specialized in helping biotechnology clients like you with process improvements, optimizing efficiencies, increasing yields, decreasing costs, and optimizing operations. Our projects range from full-scale biotechnology manufacturing facilities and secondary manufacturing facilities, pilot plants, laboratories, central utilities and warehouses.

We have unparalleled experience in commercializing first-of-a-kind processes and scale-up. When you partner with us, your finished facility will incorporate innovative solutions using state-of-the-art technology for containment, barriers, locally controlled environments, process and building systems automation, and off-the-site design and fabrication of process and building modules.

You can also expect CRB to provide a thorough understanding of the regulatory environment and the impact process design has on facility start-up and process validation. Our standard practices include GMP-oriented documentation and change control procedures that facilitate a smooth transition from design to validation.

Our operational technology expertise includes:
MICROBIAL FERMENTATION PROCESSES AND FERMENTER DESIGNCELL CULTURE SYSTEMS AND BIOREACTOR DESIGNPROTEIN ISOLATION AND PURIFICATIONFORMULATION AND BULK FILLBIOCONTAINMENT/BIOSAFETY APPLICATIONSTECHNOLOGY TRANSFER / SCALE-UPSINGLE-USE TECHNOLOGY EVALUATIONSCLEAN-IN-PLACE (CIP)STERILE PROCESSES AND SYSTEMSBIOWASTE DEACTIVATION